Regulation of Sulfated Glycoprotein-1 and Cathepsin D Expression in Adult Rat Epididymis

Regulation of the pannexin-1 promoter in the rat epididymis.

Pannexins (PANXs) are channel-forming proteins implicated in cellular communication through the secretion of biomolecules, such as ATP and glutamate. PANX1 and PANX3 are expressed in the male rat reproductive tract and their levels are regulated by androgens in the epididymis. There is currently no information on the regulation of the Panx1 promoter. The objective of the present study was to ch...

Cloning, sequence and expression of rat cathepsin D.

Cathepsin D is a member of the family of aspartic proteases and is thought to play a role in the lysosomal-mediated degradation of proteins (1). We have isolated the cDNA for rat cathepsin D from a pituitary cDNA library, screened using oligonucleotide probes synthesized to the conserved active site regions of aspartic proteases (Figure 1). The cDNA contains an open reading frame which encodes ...

Regulation of Cathepsin D Activity and Activation

Cathepsin D gene Expression in Stomach: Its Association with Age, Sex, and Menopausal status

Background & Objectives :Gastric cancer is 2-4 folds higher in men than women. Sex hormones are one of the leading causes of sexual dimorphism in incidence of gastric cancer. The aim of this study is to compare Cathepsin D and Caspase-7 gene expressions in the gastric tissue of normal men and women. Materials & Methods :In this cross-sectional study, gastric antrum tissue samples were collecte...

Expression of CD30 in Testis and Epididymis of Adult Mice

CD30 antigen is a member of the tumor necrosis factor (TNF) receptor superfamily (Smith et al., 1990; Durkop et al., 1992), which was originally identified on ReedSternberg cells of Hodgkin’s diseases (Schwab et al., 1982). CD30 was subsequently revealed to be expressed also in different non-Hodgkin’s lymphomas (NHLs), as well as in several virally transformed Tand B-cell lines (Herbst et al., ...